Cisplatin injection is a clear, colorless, sterile aqueous solution. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. Material may be irritating to the mucous membranes and upper respiratory tract. Cisplatin side effects, dosage, interactions drugs. Understanding and correcting msds file upload errors. A safety data sheet, or sds, is a standardized document that contains occupational safety and health data.
Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. Appropriate management of therapy and complications is possible only when adequate. Mixture is a suspension of cisplatin, a cytotoxic agent, in dimethyl sulfoxide dmso. The international hazard communication standard hcs mandates that chemical manufacturers must communicate a chemicals hazard information to chemical handlers by providing a safety data sheet. Material safety data sheet of cisplatin abmole bioscience. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. This agent may also interfere with amino acid, cyclic amp, and glutathione metabolism. Jul 18, 2017 cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Cisplatin or cis diamminedichloroplatinum ddp is an inorganic compound that is widely used for the treatment of a variety of tumors. Cisplatin is a member of the alkylating agents drug class and is commonly used for anal cancer, bladder cancer, blood cell transplantation, and others. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Cisplatin is also being studied in the treatment of other types of cancer.
Safety data sheets free sds database chemical safety. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following. The cleaning protocol that consists of peridox rtu cleaner and 70% ipa isopropyl alcohol prewetted wipers has shown to remove at least 99. Cisplatin is known to be substantially excreted by the kidney and is contraindicated in patients with preexisting renal impairment. Safety data sheet according to 29cfr19101200 and ghs rev.
Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Cisplatin hazard statements h300 fatal if swallowed. Red blood cell platinum concentrations decline in a biphasic manner with a terminal halflife of 36 to 47 days. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer. Because elderly patients are more likely to have decreased renal. Cisplatin hydration guidelines for outpatients introduction there is increasing demand to treat more patients as outpatients. Should be administered only by or under the direct supervision of a qualified.
Vinblastine is a natural alkaloid isolated from the plant vinca rosea linn. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. If cisplatin contacts the skin or mucosa, immediately and thoroughly wash the skin with soap and water and flush the mucosa with water. Monitor complete blood counts before initiating therapy, prior to each new cycle, and as clinically indicated. Hazardous combustion products thermal decomposition or combustion products may include the following substances. Cisplatin overdose toxicities and management request pdf.
These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. The cisplatin, with the cas registry number 15663271,is also known as cisdiaminedichloroplatinumii. From in vitro studies on isolated dna and cho cells, the adducts formed from the reaction of carboplatin with dna include the. In this study, we examined the literature and found a significant number of studies 11. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and renal function should be monitored. Cisplatin hydration for outpatients chemotherapy regimen. Dec 31, 2019 cisplatin injection is a clear, colorless, sterile aqueous solution.
Cisplatin fda prescribing information, side effects and uses. Cisplatin freezedried powder for injection material safety data sheet pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it. Cisplatin cisplatin dose, indications, adverse effects. This cisplatin price guide is based on using the discount card which is accepted at most u. Cisplatin can cause severe bone marrow suppression with fatalities due to infection. Purpose this standard operating procedure sop describes the guidelines for the use of cisplatin in rodents. It belongs to the product categories of ammine metal halide. P264 wash contaminated skin thoroughly after handling. Advice for firefighters special protective equipment for firefighters wear positivepressure selfcontained breathing apparatus scba and appropriate protective. We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. Tempol in gel form intraorally also provided almost complete protection 95%. Cisplatin dosing, indications, interactions, adverse effects.
Cisplatin is a medicine used alone or with other therapies to treat cancer of the testicles, ovaries, or bladder. Ciswel, cisplatin injection, cisplatin manufacturer, cisplatin manufacturer in india, cisplatin price in india, cisplatin cost in india, cisplatin cost effective option, cisplatin. Cisplatin is a platinumcontaining, broad activity antineoplastic and alkylating agent effective against solid tumors of testes, ovaries, and bladder. Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. The chemistry of cisplatin in aqueous solution springerlink. Cisplatin induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the fasfas ligand system. Mixture is a suspension of cisplatin, a cytotoxic agent, in dmso. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride. Precautionary statements p201 obtain special instructions before use. The information contained in each sds is based on data merck believes to be correct to the best of our knowledge at the date of its publication. Page 3 of 5 7 handling and storage precautions for safe handling. Weve included the most sought after safety data sheets, and the database just keeps growing.
Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Send us your paper safety data sheets and well professionally scan and convert them to pdf. The antitumor properties of platinumcontaining drugs are attributable in large measure to the kinetics of their ligand displacement reactions. Pharmacological protection from radiation cisplatin. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. Cisplatin 1 mgml sterile concentrate summary of product. The first metal based anticancer drug sciencedirect.
Anaphylactoid reactions have occurred during normal therapy with cisplatin and must be treated vigorously. If cisplatin contacts the skin or mucosa, immediately and thoroughly wash the skin. Only select registry of toxic effects of chemical substances rtecs data is presented. Standard operating procedure for cisplatin in animals 1. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. In order to for patients to be treated as a day case, the regimens have been modified as follows.
Material safety data sheet of cisplatin contains identification of substance and details of the supplier of the safety data sheet. As is discussed at length in other contributions to. Jul 15, 2012 if animals were pretreated with tempol 275 mgkg. Precautionary statements p202 do not handle until all safety precautions have been read and understood. Sds of cisplatin, safety data sheets, cas 15663271 chemblink. Cisplatin investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen. Merck is providing safety data sheet sds information as a service to our customers and others seeking this information. The drug is also sometimes used offlabel to treat head and neck cancers. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. The platinum compounds, in vivo, crosslink dna and interfere with cell division by mitosis. Read complete cisplatin msds ciswel manufactured by getwell oncology a leader manufacturing complex oncology generics in india. Cisplatin is one of the best and first metalbased chemotherapeutic drugs see fig. Cisplatin causes electrolyte disturbances which are a direct result of cisplatin induced renal tubular dysfunction. Cisplatin 1 mgml sterile concentrate should be diluted in 2 litres of 0.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Cisplatin 175 mgm2 undiluted in an evacuated, empty container via intraperitoneal ip injection once. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the m phase of the cell cycle. Our msds database is an easy to use, do it yourself tool, and best of all. Sigmaaldrich offers a number of cisplatin products. Cisplatin induces marked nausea and vomiting in almost all patients. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6.
Cisplatin freezedried powder for injection material safety data sheet pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is. Understanding and correcting msds file upload errors during the file upload process in msds, users will often receive a popup message indicating the file was uploaded successfully, yet sometimes the data. This information was last updated on september 5, 2003. The data on this material safety data sheet relate only to the specific material herein and do not relate to use in combination with any other material or process. Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. Standard operating procedure for cisplatin in animals. Skin reactions associated with accidental exposure to cisplatin may occur. Forms inter and intrastrand dna adductscrosslinks, consequently blocking dna replication and transcription and inducing cell death 2, 12, 15. Each 50 ml, 100 ml or 200 ml amber vial of cisplatin injection contains.
Health hazards cisplatin is a potent platinumbased antineoplastic drug which is used to treat cancers including. Platinol cisplatin for injection, usp is a white to light yellow lyophilized powder. Carboplatin product number c 2538 store at room temperature product description molecular formula. Cisplatin is one of the most widely used antineoplastic agents in the treatment of solid tumour and haematological malignancies, including cancers of the testes, ovary, bladder, head and neck. Cisplatin concentrations decrease monoexponentially with a halflife of approximately 20 to 30 minutes. Cisplatin prices, coupons and patient assistance programs. Jul 15, 2014 the platinum drugs cisplatin, carboplatin and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. It exerts its effects by covalent reaction with dna to produce interstrand and intrastrand dna crosslinks, and dnaprotein crosslinks.
Material safety datasheet 9sections section 1 product information product identifier drytype transformer whmis classification optional product use electrical manufacturers name. Only select registry of toxic effects of chemical substances rtecs data is presented here. See actual entry in rtecs for complete information. Hci andor sodium hydroxide added to adjust ph to 3. Material safety data sheet prepared according to 29 cfr 1910. P280 wear protective gloves protective clothing eye protection face protection. Cisplatin may give allergic reactions in some patients. Cisplatin is a chemotherapy medication used to treat a number of cancers.
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